Engineering advanced dynamic biomaterials to optimize adoptive T-cell immunotherapy

Adoptive T-cell therapy (ACT) is a promising therapeutic approach based on the concept of potent mediated immunity against tumor. The outcome antigen-specific T-cells responses relies interaction between and antigen-presenting cells, which provides signals for generating different phenotypes with roles in tumor removal. However, such often not optimal vivo results low efficacy. To reach full potential response, current research put effort into developing dynamic biomaterials as artificial cells to study regulate activity controlling fate. In this perspective, we provide (1) an overview ACT general behaviors, (2) explore insight how can be used studying regulating (3) discuss conceptual gaps knowledge biomaterials-based immunotherapy.